PERSPECTIVES ON ADVANCE RESEARCH DIRECTIVES FROM INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT AND FAMILY MEMBERS: A QUALITATIVE INTERVIEW STUDY

Perspectives on advance research directives from individuals with mild cognitive impairment and family members: a qualitative interview study

BackgroundAdvance research directives (ARDs) provide a promising way to involve individuals with mild cognitive impairment (MCI) in research decisions before they lose the capacity to consent.At the same time, the views of people with MCI on ARDs are underexplored.This study assesses the perceptions of people with MCI and family members on the bene

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Characterizing the Temporal Regularities of Crime

There are a lot of studies that show that Rimmers criminal activities exhibit certain temporal and spatial regularities.However, they often focus on either specific cities or types of crime and cannot clearly explain the patterns for the crime.What are the temporal patterns at the microlevel spatial scale? How general? Understanding the regularitie

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Genome-wide identification of Bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling.

B-cell leukemia/lymphoma 11B (Bcl11b) is a transcription factor showing predominant expression in the striatum.To date, there are no known gene targets of Bcl11b in the nervous system.Here, we 5.5/5RV define targets for Bcl11b in striatal cells by performing chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) in combinat

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